FAM83E

Across TCGA pan-cancer cohorts, FAM83E RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated FAM83E data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FAM83E RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM83E expression acts as an unfavorable survival marker, although some lineages such as HNSC and MESO show a favorable association.

ACC, HNSC, and KIRC are the cancer types where FAM83E RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.355	0.796	<.001	120	view →
HNSC	DFS	Median	All	0.782	0.635	<.001	113	view →
KIRC	OS	Tertile	All	0.526	0.673	<.001	81	view →
MESO	DFS	Quartile	All	0.497	0.265	.001	64	view →
KIRP	OS	Tertile	All	0.590	0.858	<.001	52	view →
SCLC	DFS	Median	III,IV	0.536	0.233	.003	43	view →
ESCA	OS	Median	All	0.418	1.000	.005	30	view →
UCS	DFS	Tertile	IV	0.843	0.250	.024	24	view →
LIHC	DFS	Tertile	III,IV	0.650	0.237	.012	21	view →
SKCM	OS	Median	All	0.264	0.393	.001	18	view →
READ	DFS	Quartile	II,III,IV	0.634	1.000	.001	12	view →
LUAD	DFS	Tertile	All	0.563	0.725	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

FAM83E–ACC (DFS)

Open the ACC breakdown →