FAM83E

Across TCGA pan-cancer cohorts, FAM83E RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FAM83E’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FAM83E RNA is repressed in tumor relative to normal tissue. In most cancer types FAM83E is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and COAD are the cancer types where FAM83E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM83E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.912	<.001	10	view →
KICH	Female	All	−1.750	<.001	7	view →
COAD	Female	II,III,IV	−0.964	<.001	7	view →
LUSC	Male	All	−1.209	<.001	5	view →
PAAD	All	All	+3.905	.009	4	view →
STAD	Male	All	+1.741	.004	4	view →
BRCA	All	All	+0.617	.003	4	view →
READ	All	III,IV	−0.940	.006	3	view →
LIHC	Male	All	−0.228	<.001	3	view →
CHOL	Male	All	+2.263	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FAM83E–KIRC

Open the KIRC breakdown →