FAM83E

Across TCGA patient cohorts, FAM83E mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. COAD shows the largest number of these associations.

The most reproducible FAM83E-associated genes across cancer lineages are MEK1, MSH2, and Smad4. Each is linked with FAM83E in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM83E-to-partner and partner-to-FAM83E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by FAM83E-low versus FAM83E-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM83E→partner) and Y-score (partner→FAM83E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MEK1 →	+0.208	+2.347	.020	.019	3	2
COAD	MSH2 →	-0.217	-3.144	.032	.018	3	2
COAD	Smad4 →	+0.152	+3.000	.011	.035	3	2
SKCM	c-Kit →	-0.641	-2.321	.049	.035	3	2
UCEC	PDK1_pS241 →	+0.253	+2.820	.015	.036	3	1
UCEC	14-3-3_zeta →	+0.309	+2.833	.014	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MEK1 by FAM83E expression — COAD

Explore this box plot interactively →