FAM83E

Across TCGA cell cohorts, FAM83E mutation is significantly associated with the mutation status of many other genes, with 2,517 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM83E-associated genes across cancer lineages are GLI3, CACNA1E, and TNS2. Each is linked with FAM83E in more than 3 cancer types. Because this analysis shows association rather than direction, both FAM83E-to-partner and partner-to-FAM83E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLI3 grouped by FAM83E-low versus FAM83E-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM83E→partner) and Y-score (partner→FAM83E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GLI3 →	+5.000	+5.000	.006	.006	1	4
KIDNEY	CACNA1E →	+5.000	+5.000	.006	.006	1	4
OVARY	TNS2 →	+4.099	+3.760	<.001	<.001	1	4
OVARY	ZFP64 →	+4.684	+3.562	.002	.002	1	4
SKIN	SLC7A2 →	+5.392	+4.824	.004	.004	1	4
BLOOD_Leukemia	TENM1 →	+3.020	+4.545	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,517 associations by consensus.

GLI3 by FAM83E expression — KIDNEY

Explore this box plot interactively →