FAM74A3

Across TCGA patient cohorts, FAM74A3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,683 significant associations in total. STAD shows the largest number of these associations.

The most reproducible FAM74A3-associated GO terms across cancer lineages are Negative regulation of supramolecular fiber organization, Extracellular matrix assembly, and Negative regulation of cell-substrate junction organization. Each is linked with FAM74A3 in more than 10 cancer types. Because this analysis shows association rather than direction, both FAM74A3-to-partner and partner-to-FAM74A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of supramolecular fiber organization grouped by FAM74A3-low versus FAM74A3-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM74A3→partner) and Y-score (partner→FAM74A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Negative regulation of supramolecular fiber organization →	+0.083	+0.100	<.001	<.001	3	11
STAD	Extracellular matrix assembly →	+0.099	+0.092	<.001	<.001	3	11
STAD	Negative regulation of cell-substrate junction organization →	+0.101	+0.097	<.001	<.001	3	11
STAD	Regulation of cell-matrix adhesion →	+0.105	+0.096	<.001	<.001	3	10
STAD	Heart valve development →	+0.084	+0.086	<.001	<.001	3	10
STAD	Glucose metabolic process →	+0.092	+0.084	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,683 associations by consensus.

Negative regulation of supramolecular fiber organization by FAM74A3 expression — STAD

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