FAM74A3

Across TCGA pan-cancer cohorts, FAM74A3 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of FAM74A3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FAM74A3 RNA is repressed in tumor relative to normal tissue. In most cancer types FAM74A3 is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where FAM74A3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM74A3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.103	<.001	10	view →
HNSC	All	All	−0.059	.016	7	view →
KIRP	All	All	−0.063	.004	4	view →
BRCA	Female	All	−0.056	<.001	4	view →
COAD	All	II,III,IV	−0.021	.020	4	view →
READ	All	All	−0.191	.031	2	view →
UCEC	All	All	−0.073	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

FAM74A3–KIRC

Open the KIRC breakdown →