Across TCGA patient cohorts, FAM66C mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM66C-associated genes across cancer lineages are IGKV1OR2-118, IGKV1OR2-9, and IGKV2OR2-2. Each is linked with FAM66C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM66C-to-partner and partner-to-FAM66C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM66C→partner) and Y-score (partner→FAM66C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGKV1OR2-118 →	+0.313	+3.496	.005	.005	3	1
UCEC	IGKV1OR2-9 →	+0.496	+3.277	.001	.009	3	1
UCEC	IGKV2OR2-2 →	+0.171	+3.759	.006	.005	3	1
UCEC	NF1P7 →	+0.091	+3.525	.009	.008	3	1
UCEC	MIR7849 →	+0.497	+4.133	<.001	.002	3	1
UCEC	MIR548AL →	+0.363	+4.226	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

FAM66C survival (RNA) · tumor vs normal (RNA) · all FAM66C data types