FAM237A

Across TCGA patient cohorts, FAM237A mutation is significantly associated with the RNA expression of many other genes, with 258 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM237A-associated genes across cancer lineages are RITA1, RNU6-752P, and LINC01965. Each is linked with FAM237A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM237A-to-partner and partner-to-FAM237A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RITA1 grouped by FAM237A-low versus FAM237A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM237A→partner) and Y-score (partner→FAM237A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RITA1 →	+0.503	+3.202	.004	.009	3	2
SKCM	RNU6-752P →	+0.182	+4.212	<.001	.007	3	2
SKCM	LINC01965 →	+0.011	+3.360	.003	.006	3	2
SKCM	PPIAP10 →	+0.181	+2.729	<.001	.009	3	2
UCEC	RNU6-618P →	+0.327	+3.384	.002	<.001	3	2
LUSC	RNU6-1149P →	+0.688	+3.891	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 258 associations by consensus.

RITA1 by FAM237A expression — UCEC

Explore this box plot interactively →