FAM237A

Across TCGA pan-cancer cohorts, FAM237A RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FAM237A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM237A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM237A is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

HNSC, BRCA, and LUSC are the cancer types where FAM237A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM237A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.106	.003	6	view →
BRCA	All	All	−0.036	<.001	6	view →
LUSC	All	All	+0.205	.002	2	view →
THCA	Male	All	−0.014	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

FAM237A–HNSC

Open the HNSC breakdown →