FAM230A

Across TCGA patient cohorts, FAM230A mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM230A-associated genes across cancer lineages are PPP3R2, RNU6-23P, and PRAMEF7. Each is linked with FAM230A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM230A-to-partner and partner-to-FAM230A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP3R2 grouped by FAM230A-low versus FAM230A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM230A→partner) and Y-score (partner→FAM230A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP3R2 →	+0.098	+3.185	<.001	.006	3	1
UCEC	RNU6-23P →	+0.492	+3.382	<.001	.004	3	1
UCEC	PRAMEF7 →	+0.235	+3.734	<.001	.001	3	1
UCEC	RNU6-1292P →	+0.504	+4.132	<.001	.009	3	1
UCEC	RNU6-1029P →	+0.347	+3.386	<.001	.008	3	1
UCEC	RNU6-784P →	+0.309	+3.520	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

PPP3R2 by FAM230A expression — UCEC

Explore this box plot interactively →