Across TCGA pan-cancer cohorts, FAM230A RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of FAM230A’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where FAM230A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM230A is over-expressed in tumor.
LIHC and THCA are the cancer types where FAM230A tumor–normal differential expression is most reproducible.