FAM227B

Across TCGA cell cohorts, FAM227B mutation is significantly associated with the RNA expression of many other genes, with 374 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM227B-associated genes across cancer lineages are FAM205C, TRIM64B, and GSPT1. Each is linked with FAM227B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM227B-to-partner and partner-to-FAM227B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM205C grouped by FAM227B-low versus FAM227B-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM227B→partner) and Y-score (partner→FAM227B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM205C →	+0.088	+5.029	<.001	.006	3	1
LUNG_SCLC	TRIM64B →	+0.066	+5.029	<.001	.006	3	1
LARGE_INTESTINE	GSPT1 →	+0.517	+3.212	.006	.006	3	1
LARGE_INTESTINE	CLUAP1 →	+0.644	+3.082	.004	.007	3	1
LARGE_INTESTINE	SH3GL2 →	+1.331	+3.474	<.001	.003	3	1
LARGE_INTESTINE	GAR1 →	+0.718	+3.299	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 374 associations by consensus.

FAM205C by FAM227B expression — LUNG_SCLC

Explore this box plot interactively →