FAM227B

Across TCGA pan-cancer cohorts, FAM227B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FAM227B’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FAM227B RNA is repressed in tumor relative to normal tissue. In most cancer types FAM227B is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where FAM227B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM227B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.772	<.001	11	view →
KIRC	Male	III,IV	−0.469	<.001	11	view →
KICH	Female	II,III,IV	−1.442	<.001	10	view →
KIRP	All	All	−0.639	<.001	7	view →
UCEC	All	All	−0.656	<.001	4	view →
LUAD	Female	II,III,IV	−0.331	.005	3	view →
CHOL	All	All	+0.578	.009	2	view →
BLCA	Male	III,IV	−0.707	.041	1	view →
LUSC	All	III,IV	−0.605	.013	1	view →
ESCA	Female	All	−0.376	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FAM227B–THCA

Open the THCA breakdown →