FAM222A

Across TCGA cell cohorts, FAM222A mutation is significantly associated with the mutation status of many other genes, with 1,368 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FAM222A-associated genes across cancer lineages are ERGIC3, TUBB1, and SAMHD1. Each is linked with FAM222A in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM222A-to-partner and partner-to-FAM222A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERGIC3 grouped by FAM222A-low versus FAM222A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM222A→partner) and Y-score (partner→FAM222A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ERGIC3 →	+5.321	+5.894	.002	.002	1	3
BLOOD_Leukemia	TUBB1 →	+4.000	+5.050	.008	.008	1	3
LARGE_INTESTINE	SAMHD1 →	+5.087	+4.523	.006	.006	1	3
LUNG_SCLC	SIM2 →	+5.502	+5.502	.003	.003	1	3
LUNG_SCLC	GAN →	+5.502	+5.502	.003	.003	1	3
LARGE_INTESTINE	ZNF205 →	+2.865	+4.217	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,368 associations by consensus.

ERGIC3 by FAM222A expression — BLOOD_Leukemia

Explore this box plot interactively →