FAM222A

Across TCGA pan-cancer cohorts, FAM222A RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated FAM222A data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher FAM222A RNA is associated with better overall survival. In most high-consensus cancer types, elevated FAM222A expression acts as an unfavorable survival marker, although some lineages such as SCLC and HNSC show a favorable association.

SCLC, MESO, and HNSC are the cancer types where FAM222A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Quartile	II,III,IV	0.905	0.422	<.001	91	view →
MESO	OS	Median	All	0.426	0.654	<.001	81	view →
HNSC	DFS	Median	IV	0.720	0.561	.001	51	view →
LGG	DFS	Median	All	0.834	0.641	<.001	50	view →
CESC	OS	Tertile	All	0.872	0.690	<.001	48	view →
PAAD	OS	Tertile	All	0.607	0.266	<.001	48	view →
KIRP	DFS	Median	III,IV	0.231	0.562	.002	38	view →
READ	DFS	Median	III,IV	0.832	0.640	.011	26	view →
UCS	DFS	Tertile	II,III,IV	0.575	0.161	.003	24	view →
LUAD	DFS	Median	All	0.741	0.837	<.001	22	view →
LIHC	OS	Tertile	All	0.712	0.866	.004	20	view →
ACC	OS	Quartile	All	0.435	0.924	.016	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

FAM222A–SCLC (OS)

Open the SCLC breakdown →