FAM221B

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, FAM221B mutation is significantly associated with the RNA expression of many other genes, with 597 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM221B-associated genes across cancer lineages are ABCD1P3, MIR4472-2, and RN7SL803P. Each is linked with FAM221B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM221B-to-partner and partner-to-FAM221B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM221B→partner) and Y-score (partner→FAM221B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMABCD1P3 →+0.035+3.265<.001.00632
SKCMMIR4472-2 →+0.222+2.726.007.00732
SKCMRN7SL803P →+0.079+3.027<.001.00132
LUSCPPIAP38 →+0.125+4.484.009.00232
UCECEIF1P7 →+0.448+3.600.004.00132
UCECHMGB1P20 →+0.372+2.743<.001.00332
Each partner links to its Q-omics profile. Showing the 6 strongest of 597 associations by consensus.

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