Across TCGA pan-cancer cohorts, FAM221B RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FAM221B’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FAM221B RNA is repressed in tumor relative to normal tissue. In most cancer types FAM221B is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.
KIRC, LIHC, and THCA are the cancer types where FAM221B tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM221B RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.