FAM214A

Across TCGA patient cohorts, FAM214A mutation is significantly associated with the RNA expression of many other genes, with 3,255 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM214A-associated genes across cancer lineages are KISS1R, RN7SKP65, and RPL23AP72. Each is linked with FAM214A in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM214A-to-partner and partner-to-FAM214A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KISS1R grouped by FAM214A-low versus FAM214A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM214A→partner) and Y-score (partner→FAM214A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KISS1R →	+0.770	+2.337	.002	.003	3	3
READ	RN7SKP65 →	+0.103	+4.672	<.001	.004	3	2
READ	RPL23AP72 →	+0.175	+4.267	.002	.003	3	2
READ	RN7SL66P →	+0.120	+4.341	<.001	.007	3	2
READ	MIR6801 →	+0.447	+3.827	<.001	.006	3	2
COAD	ZNF232 →	+0.556	+3.486	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,255 associations by consensus.

KISS1R by FAM214A expression — UCEC

Explore this box plot interactively →