FAM214A

Across TCGA pan-cancer cohorts, FAM214A RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of FAM214A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FAM214A RNA is repressed in tumor relative to normal tissue. In most cancer types FAM214A is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, KIRC, and HNSC are the cancer types where FAM214A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM214A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.011	<.001	9	view →
KIRC	All	All	+0.415	<.001	9	view →
HNSC	Male	All	−0.725	<.001	7	view →
THCA	All	All	−0.455	<.001	7	view →
LUSC	Male	II,III,IV	−0.561	<.001	6	view →
READ	Female	All	−1.335	<.001	5	view →
UCEC	All	All	−0.434	.021	2	view →
PRAD	All	All	+0.269	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

FAM214A–COAD

Open the COAD breakdown →