FAM186B

Across TCGA patient cohorts, FAM186B mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM186B-associated genes across cancer lineages are ASNS, eEF2, and eIF4E. Each is linked with FAM186B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM186B-to-partner and partner-to-FAM186B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by FAM186B-low versus FAM186B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM186B→partner) and Y-score (partner→FAM186B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.742	+3.169	<.001	.018	3	3
UCEC	eEF2 →	+0.364	+1.440	.003	.024	3	2
UCEC	eIF4E →	+0.200	+2.459	.006	<.001	2	3
UCEC	GAPDH →	+0.389	+1.700	.036	.040	3	2
UCEC	INPP4B →	-0.223	-2.321	.046	.005	3	2
UCEC	JNK2 →	+0.203	+2.486	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ASNS by FAM186B expression — COAD

Explore this box plot interactively →