FAM186B

Across TCGA cell cohorts, FAM186B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,267 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FAM186B-associated GO terms across cancer lineages are Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and mRNA alternative polyadenylation. Each is linked with FAM186B in more than 15 cancer types. Because this analysis shows association rather than direction, both FAM186B-to-partner and partner-to-FAM186B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by FAM186B-low versus FAM186B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM186B→partner) and Y-score (partner→FAM186B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.165	+0.417	<.001	<.001	3	16
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.160	+0.392	<.001	<.001	3	15
BONE	mRNA alternative polyadenylation →	+0.114	+0.510	<.001	<.001	2	15
OESOPHAGUS	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.172	+0.379	.004	.005	3	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA metabolic process →	+0.071	+0.335	.001	.002	3	14
BONE	Double-strand break repair →	+0.107	+0.540	.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,267 associations by consensus.

Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I by FAM186B expression — BONE

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