FAM182B

Across TCGA patient cohorts, FAM182B mutation is significantly associated with the RNA expression of many other genes, with 681 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM182B-associated genes across cancer lineages are PTPRJ, PRSS53, and FAM177A1. Each is linked with FAM182B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM182B-to-partner and partner-to-FAM182B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTPRJ grouped by FAM182B-low versus FAM182B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM182B→partner) and Y-score (partner→FAM182B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PTPRJ →	+0.825	+3.480	<.001	.002	3	1
UCEC	PRSS53 →	+0.292	+2.190	.002	.009	3	1
UCEC	FAM177A1 →	+0.488	+3.354	<.001	.005	3	1
UCEC	CWF19L2 →	+0.521	+2.807	.009	.003	3	1
UCEC	USP12 →	+0.542	+2.640	.003	.005	3	1
UCEC	TRIM36 →	+1.160	+3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 681 associations by consensus.

PTPRJ by FAM182B expression — UCEC

Explore this box plot interactively →