Across TCGA patient cohorts, FAM180A mutation is significantly associated with the RNA expression of many other genes, with 122 significant associations in total. COAD shows the largest number of these associations.

The most reproducible FAM180A-associated genes across cancer lineages are HMGB3P16, GPAA1P1, and RNY4P20. Each is linked with FAM180A in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM180A-to-partner and partner-to-FAM180A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM180A→partner) and Y-score (partner→FAM180A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	HMGB3P16 →	+0.163	+5.578	<.001	.002	3	3
LUAD	GPAA1P1 →	+0.038	+4.584	<.001	.005	3	2
LUAD	RNY4P20 →	+0.221	+4.739	.002	.004	3	2
BRCA	RNU6-532P →	+0.171	+7.471	<.001	.008	3	2
UCEC	TRAJ50 →	+1.098	+4.420	<.001	.001	3	2
LUSC	MIR103A1 →	+0.366	+4.706	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 122 associations by consensus.

Exploration

FAM180A survival (RNA) · tumor vs normal (RNA) · all FAM180A data types