Q-omics provides the consensus-scored HMGB3P16 profile across patient tissues and cancer cell-line models. HMGB3P16 expression is associated with patient survival in 12 of 34 cancer types, with the highest sampling consensus in BRCA. Additionally, HMGB3P16 RNA expression shows 5,697 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight BRCA, and STAD as cancer lineages where HMGB3P16 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes HMGB3P16 survival associations across molecular data types. HMGB3P16 RNA expression shows survival associations in the most cancer types (12). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

HMGB3P16 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	12	BRCA (108)	view →

This table ranks reproducible HMGB3P16 RNA expression–survival associations across cancer types. High HMGB3P16 expression shows unfavorable associations in BRCA, COAD, UCEC, KIRC, STAD and DLBC. The BRCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify BRCA as the clearest survival context for HMGB3P16 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	All	0.398	0.905	<.001	108	view →
COAD	OS	Tertile	II,III,IV	0.054	0.860	<.001	81	view →
UCEC	DFS	Tertile	III,IV	0.532	0.803	.018	54	view →
KIRC	DFS	Tertile	All	0.444	0.632	.005	30	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	27	view →
DLBC	OS	Tertile	All	0.473	0.945	.006	27	view →

Pink = unfavorable, green = favorable. all 12 lineages →

HMGB3P16-BRCA (DFS)

Kaplan–Meier survival curve for HMGB3P16 RNA expression in BRCA: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with HMGB3P16 in patient tissues and cancer cell lines. In patient samples, HMGB3P16 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	5,697	STAD (5514)	view →
Protein (mass-spec)	3,966	LSCC (1975)	view →