Across TCGA pan-cancer cohorts, FAM180A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FAM180A’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where FAM180A RNA is repressed in tumor relative to normal tissue. In most cancer types FAM180A is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.
KICH, KIRC, and THCA are the cancer types where FAM180A tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM180A RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.