FAM171B

Across TCGA patient cohorts, FAM171B mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM171B-associated genes across cancer lineages are Caspase-7-cleavedD198, Rab25, and ASNS. Each is linked with FAM171B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM171B-to-partner and partner-to-FAM171B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FAM171B-low versus FAM171B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM171B→partner) and Y-score (partner→FAM171B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.891	+2.807	<.001	.002	3	3
UCEC	Rab25 →	-0.496	-3.584	<.001	.002	3	3
UCEC	ASNS →	+0.647	+3.999	<.001	<.001	3	3
LUAD	HSP70 →	+0.644	+3.000	.011	.035	3	2
LUSC	IRS1 →	+0.193	+2.816	.001	.036	3	2
UCEC	EGFR_pY1068 →	-0.295	-2.087	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Caspase-7-cleavedD198 by FAM171B expression — UCEC

Explore this box plot interactively →