FAM171B

Across TCGA pan-cancer cohorts, FAM171B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FAM171B’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where FAM171B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM171B is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

BLCA, LIHC, and LUAD are the cancer types where FAM171B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM171B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+1.036	<.001	8	view →
LIHC	Male	All	+0.486	<.001	8	view →
LUAD	Male	II,III,IV	+1.243	<.001	7	view →
CHOL	All	All	+1.507	<.001	5	view →
KICH	Female	All	−1.249	<.001	5	view →
LUSC	Male	All	+1.042	<.001	4	view →
COAD	All	All	−0.384	.005	4	view →
HNSC	All	III,IV	+0.610	.047	2	view →
READ	Female	All	−1.310	.016	1	view →
ESCA	Male	All	+1.056	.029	1	view →
KIRP	All	III,IV	+0.985	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FAM171B–BLCA

Open the BLCA breakdown →