FAM167A

Across TCGA patient cohorts, FAM167A mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM167A-associated genes across cancer lineages are MSH2, Akt_pT308, and Tuberin_pT1462. Each is linked with FAM167A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM167A-to-partner and partner-to-FAM167A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by FAM167A-low versus FAM167A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM167A→partner) and Y-score (partner→FAM167A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.236	-3.143	.011	.018	3	2
UCEC	Akt_pT308 →	+0.503	+2.321	.047	.033	3	2
UCEC	Tuberin_pT1462 →	+0.262	+1.884	.004	.030	3	2
UCEC	G6PD →	-0.282	-2.986	.030	.035	3	1
UCEC	INPP4B →	-0.268	-2.459	.039	.019	3	1
UCEC	MEK1 →	+0.504	+2.415	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MSH2 by FAM167A expression — UCEC

Explore this box plot interactively →