FAM167A

Across TCGA pan-cancer cohorts, FAM167A RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated FAM167A data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAM167A RNA is associated with better overall survival. In most high-consensus cancer types, elevated FAM167A expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

HNSC, ACC, and KIRC are the cancer types where FAM167A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.415	0.189	<.001	116	view →
ACC	OS	Quartile	All	0.731	1.000	<.001	112	view →
KIRC	DFS	Quartile	II,III,IV	0.661	0.857	.006	62	view →
COAD	DFS	Median	III,IV	0.772	0.518	<.001	57	view →
LGG	DFS	Tertile	All	0.505	0.278	<.001	48	view →
UCEC	OS	Tertile	All	0.492	0.809	<.001	46	view →
SKCM	OS	Median	II,III,IV	0.678	0.785	.003	34	view →
MESO	OS	Quartile	All	0.511	0.280	.014	12	view →
READ	OS	Tertile	II,III,IV	0.973	0.554	.008	10	view →
THYM	DFS	Quartile	III,IV	0.640	1.000	.044	9	view →
SCLC	DFS	Median	III,IV	0.338	0.968	.024	6	view →
CESC	DFS	Median	IV	0.427	0.096	.045	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

FAM167A–HNSC (OS)

Open the HNSC breakdown →