FAM166C

Across TCGA patient cohorts, FAM166C mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM166C-associated genes across cancer lineages are MTCO2P24, RPS10-NUDT3, and IGKV2OR2-2. Each is linked with FAM166C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM166C-to-partner and partner-to-FAM166C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO2P24 grouped by FAM166C-low versus FAM166C-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM166C→partner) and Y-score (partner→FAM166C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTCO2P24 →	+0.102	+5.327	<.001	.002	3	2
UCEC	RPS10-NUDT3 →	+0.383	+3.531	<.001	.005	3	1
UCEC	IGKV2OR2-2 →	+0.127	+3.174	.008	.002	3	1
UCEC	POM121C →	+0.496	+3.223	.007	.009	3	1
UCEC	MIR6780B →	+0.488	+3.304	<.001	.002	3	1
UCEC	SNX3P1Y →	+0.179	+5.478	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

MTCO2P24 by FAM166C expression — LUAD

Explore this box plot interactively →