FAM166C

Across TCGA pan-cancer cohorts, FAM166C RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FAM166C’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FAM166C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM166C is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, KICH, and THCA are the cancer types where FAM166C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM166C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+2.615	<.001	11	view →
KICH	Female	III,IV	−1.366	<.001	10	view →
THCA	Male	III,IV	−1.508	<.001	9	view →
KIRC	Male	All	−0.321	<.001	8	view →
READ	All	II,III,IV	+2.702	<.001	7	view →
STAD	All	All	+0.981	<.001	4	view →
CHOL	Female	All	+1.093	<.001	3	view →
PAAD	Female	All	+1.835	.031	2	view →
LUSC	Female	II,III,IV	−0.608	<.001	1	view →
KIRP	All	All	+0.458	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FAM166C–COAD

Open the COAD breakdown →