FAM166C

Across TCGA cell cohorts, FAM166C mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM166C-associated genes across cancer lineages are TEX28, ACSM6, and CFHR2. Each is linked with FAM166C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM166C-to-partner and partner-to-FAM166C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX28 grouped by FAM166C-low versus FAM166C-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM166C→partner) and Y-score (partner→FAM166C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TEX28 →	+0.025	+5.196	<.001	.005	3	1
LARGE_INTESTINE	ACSM6 →	+0.027	+4.169	<.001	.007	3	1
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TEX28 by FAM166C expression — OVARY

Explore this box plot interactively →