FAM161B

Across TCGA patient cohorts, FAM161B mutation is significantly associated with the RNA expression of many other genes, with 915 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM161B-associated genes across cancer lineages are RNA5SP412, RNU5E-8P, and RNU6-1207P. Each is linked with FAM161B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM161B-to-partner and partner-to-FAM161B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by FAM161B-low versus FAM161B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM161B→partner) and Y-score (partner→FAM161B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.600	+2.315	<.001	.002	3	2
LUSC	RNU5E-8P →	+0.456	+5.569	<.001	<.001	3	2
COAD	RNU6-1207P →	+0.415	+3.452	<.001	.002	3	2
UCEC	PITPNB →	+0.388	+2.354	.009	.003	3	2
UCEC	GP1BA →	+0.471	+3.064	<.001	<.001	3	2
UCEC	NF2 →	+0.546	+2.332	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 915 associations by consensus.

RNA5SP412 by FAM161B expression — UCEC

Explore this box plot interactively →