FAM161B

Across TCGA pan-cancer cohorts, FAM161B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FAM161B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FAM161B RNA is repressed in tumor relative to normal tissue. In most cancer types FAM161B is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and KICH are the cancer types where FAM161B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM161B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.076	<.001	11	view →
THCA	Male	II,III,IV	−0.676	<.001	10	view →
KICH	Female	II,III,IV	−1.665	<.001	9	view →
LIHC	Female	II,III,IV	+0.698	<.001	7	view →
UCEC	All	All	−1.090	<.001	6	view →
KIRC	All	II,III,IV	−0.398	<.001	6	view →
READ	All	All	−1.212	<.001	5	view →
BLCA	Male	IV	−1.185	<.001	5	view →
STAD	All	All	−0.500	.001	5	view →
LUSC	All	II,III,IV	−0.492	<.001	5	view →
PAAD	All	All	+0.665	<.001	4	view →
BRCA	Female	All	−0.253	.021	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FAM161B–COAD

Open the COAD breakdown →