FAM161B

Across TCGA pan-cancer cohorts, FAM161B RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated FAM161B data layer compared with 2 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher FAM161B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM161B expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KICH, KIRC, and BRCA are the cancer types where FAM161B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.667	0.976	<.001	75	view →
KIRC	OS	Median	All	0.727	0.550	<.001	74	view →
BRCA	OS	Tertile	II,III,IV	0.949	0.878	.001	42	view →
ACC	DFS	Tertile	All	0.184	0.644	.001	32	view →
UCS	DFS	Median	IV	0.885	0.440	.015	30	view →
STAD	DFS	Tertile	IV	0.145	0.609	.008	24	view →
LUSC	DFS	Quartile	III,IV	0.537	0.780	.006	19	view →
MESO	OS	Tertile	III,IV	0.700	0.219	.006	18	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →
THCA	DFS	Median	All	0.881	0.781	.018	10	view →
LGG	DFS	Median	All	0.461	0.330	.019	9	view →
LUAD	DFS	Quartile	All	0.835	0.719	.011	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

FAM161B–KICH (DFS)

Open the KICH breakdown →