FAM161B

Across TCGA patient cohorts, FAM161B mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM161B-associated genes across cancer lineages are ASNS, eIF4E, and FASN. Each is linked with FAM161B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM161B-to-partner and partner-to-FAM161B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by FAM161B-low versus FAM161B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM161B→partner) and Y-score (partner→FAM161B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.653	+2.700	<.001	.006	3	3
UCEC	eIF4E →	+0.236	+2.906	.008	.001	3	1
UCEC	FASN →	+0.549	+2.321	<.001	.034	3	1
UCEC	FoxM1 →	+0.234	+1.700	.033	.044	3	1
UCEC	ACC_pS79 →	+0.399	+2.321	.006	.033	3	1
UCEC	MEK1 →	+0.368	+3.459	.017	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ASNS by FAM161B expression — UCEC

Explore this box plot interactively →