FAM13B

Across TCGA patient cohorts, FAM13B mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM13B-associated genes across cancer lineages are Di-Ras3, A-Raf_pS299, and ERK2. Each is linked with FAM13B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM13B-to-partner and partner-to-FAM13B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by FAM13B-low versus FAM13B-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM13B→partner) and Y-score (partner→FAM13B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Di-Ras3 →	+0.218	+2.841	.005	.035	3	2
UCEC	A-Raf_pS299 →	-0.164	-1.906	<.001	.015	3	2
UCEC	ERK2 →	+0.139	+1.906	.031	.014	3	2
UCEC	MEK1 →	+0.314	+2.000	.010	.009	3	2
UCEC	Notch1 →	+0.126	+1.594	.007	.021	3	2
UCEC	Akt_pT308 →	+0.467	+1.807	.026	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Di-Ras3 by FAM13B expression — BLCA

Explore this box plot interactively →