FAM13B

Across TCGA pan-cancer cohorts, FAM13B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated FAM13B data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FAM13B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM13B expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUAD show a favorable association.

KIRC, LUAD, and HNSC are the cancer types where FAM13B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.726	0.544	<.001	154	view →
LUAD	OS	Quartile	All	0.866	0.739	.001	51	view →
HNSC	DFS	Median	III,IV	0.748	0.610	.004	48	view →
LGG	OS	Tertile	All	0.731	0.878	<.001	38	view →
SARC	OS	Tertile	All	0.860	0.598	.001	27	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
COAD	OS	Tertile	II,III,IV	0.884	0.648	.003	23	view →
LUSC	DFS	Tertile	III,IV	0.230	0.583	.004	23	view →
LIHC	OS	Median	All	0.713	0.848	.002	22	view →
BRCA	DFS	Quartile	III,IV	0.937	0.818	.021	15	view →
UVM	DFS	Median	III,IV	0.283	0.671	.016	14	view →
CHOL	DFS	Median	All	0.727	0.227	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

FAM13B–KIRC (DFS)

Open the KIRC breakdown →