FAM13B

Across TCGA pan-cancer cohorts, FAM13B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FAM13B’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FAM13B RNA is repressed in tumor relative to normal tissue. In most cancer types FAM13B is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and LUAD are the cancer types where FAM13B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM13B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.805	<.001	10	view →
COAD	Male	II,III,IV	−0.750	<.001	9	view →
LUAD	Female	III,IV	−1.221	<.001	8	view →
LUSC	Female	II,III,IV	−1.194	<.001	8	view →
BLCA	All	All	−0.943	.002	8	view →
LIHC	Female	All	+0.570	<.001	7	view →
UCEC	All	All	−0.983	<.001	6	view →
KIRP	Male	All	−0.641	<.001	6	view →
BRCA	Female	All	−0.505	<.001	6	view →
KICH	All	All	−0.735	<.001	4	view →
CHOL	All	All	+1.754	<.001	3	view →
READ	All	All	−1.077	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FAM13B–THCA

Open the THCA breakdown →