FAM138E

Across TCGA pan-cancer cohorts, FAM138E RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated FAM138E data layer compared with 1 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FAM138E RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM138E expression acts as an unfavorable survival marker, although some lineages such as LAML and ESCA show a favorable association.

ACC, UVM, and KIRC are the cancer types where FAM138E RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.173	0.656	<.001	102	view →
UVM	DFS	Tertile	II,III,IV	0.497	0.820	<.001	96	view →
KIRC	OS	Tertile	All	0.522	0.725	<.001	85	view →
HNSC	DFS	Tertile	III,IV	0.232	0.642	<.001	63	view →
KIRP	OS	Quartile	II,III,IV	0.578	0.861	.003	32	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	30	view →
LGG	DFS	Tertile	All	0.711	0.838	.008	27	view →
UCEC	OS	Tertile	All	0.846	0.929	.022	24	view →
LAML	DFS	Tertile	All	0.712	0.308	.007	18	view →
PAAD	OS	Tertile	II,III,IV	0.256	0.625	.028	9	view →
GBM	OS	Tertile	All	0.160	0.430	.017	9	view →
STAD	DFS	Tertile	All	0.561	0.731	.043	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

FAM138E–ACC (OS)

Open the ACC breakdown →