Q-omics provides the consensus-scored FAM138E profile across patient tissues and cancer cell-line models. FAM138E expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, FAM138E is differentially expressed in 1, with the highest sampling consensus in BLCA. Additionally, FAM138E RNA expression shows 5,868 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight ACC, BLCA, and STAD as cancer lineages where FAM138E shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM138E — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM138E survival associations across molecular data types. FAM138E RNA expression shows survival associations in the most cancer types (13), followed by mutation status (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM138E RNA expression–survival associations across cancer types. High FAM138E expression shows unfavorable associations in ACC, UVM, KIRC, HNSC, KIRP and KICH. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for FAM138E RNA expression.
This table summarizes FAM138E tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in BLCA for RNA.
This table ranks reproducible tumor–normal expression differences for FAM138E. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM138E shows lower tumor expression in BLCA. The BLCA box plot shows higher FAM138E RNA expression in normal versus tumor tissue (log2 FC = −0.118, t-test p = .022).
This table shows molecular features associated with FAM138E in patient tissues and cancer cell lines. In patient samples, FAM138E shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
