FAM122C

Across TCGA patient cohorts, FAM122C mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM122C-associated genes across cancer lineages are JNK2, Ku80, and Notch1. Each is linked with FAM122C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM122C-to-partner and partner-to-FAM122C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by FAM122C-low versus FAM122C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM122C→partner) and Y-score (partner→FAM122C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.204	+2.009	.005	.017	3	1
UCEC	Ku80 →	+0.188	+1.515	.030	.018	3	1
UCEC	Notch1 →	+0.106	+1.847	.040	.008	3	1
UCEC	STAT3_pY705 →	-0.373	-1.502	<.001	.030	3	1
UCEC	Tuberin →	+0.286	+2.459	.003	.018	3	1
UCEC	Caspase-8 →	-0.263	-3.880	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

JNK2 by FAM122C expression — UCEC

Explore this box plot interactively →