FAM122C

Across TCGA pan-cancer cohorts, FAM122C RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated FAM122C data layer compared with 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FAM122C RNA is associated with better overall survival. In most high-consensus cancer types, elevated FAM122C expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

LUAD, SKCM, and LGG are the cancer types where FAM122C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.801	0.617	<.001	88	view →
SKCM	OS	Median	All	0.402	0.260	<.001	63	view →
LGG	DFS	Median	All	0.656	0.813	<.001	54	view →
ACC	DFS	Quartile	All	0.209	0.745	<.001	41	view →
PAAD	DFS	Quartile	All	0.561	0.294	.001	25	view →
UVM	DFS	Tertile	III,IV	0.240	0.854	.001	24	view →
SCLC	OS	Median	All	0.609	0.939	.024	20	view →
LIHC	DFS	Median	III,IV	0.321	0.095	.013	17	view →
BRCA	OS	Quartile	III,IV	0.934	0.822	.018	15	view →
HNSC	DFS	Quartile	All	0.767	0.643	.010	13	view →
KIRC	DFS	Tertile	IV	0.187	0.497	.011	10	view →
LUSC	DFS	Median	II,III,IV	0.542	0.674	.011	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

FAM122C–LUAD (OS)

Open the LUAD breakdown →