FAM122C

Across TCGA pan-cancer cohorts, FAM122C RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FAM122C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM122C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM122C is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

HNSC, CHOL, and COAD are the cancer types where FAM122C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM122C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.349	<.001	7	view →
CHOL	Female	All	+0.563	<.001	5	view →
COAD	All	All	+0.229	<.001	5	view →
LIHC	All	All	+0.210	<.001	5	view →
LUSC	All	III,IV	−0.559	.004	4	view →
KICH	All	All	−0.409	<.001	4	view →
THCA	All	All	−0.138	.004	4	view →
UCEC	All	All	−0.538	.012	2	view →
BLCA	Male	IV	−0.402	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FAM122C–HNSC

Open the HNSC breakdown →