FA2H

Across TCGA patient cohorts, FA2H mutation is significantly associated with the RNA expression of many other genes, with 704 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FA2H-associated genes across cancer lineages are RN7SKP286, HMGN2P26, and RN7SL553P. Each is linked with FA2H in more than 1 cancer types. Because this analysis shows association rather than direction, both FA2H-to-partner and partner-to-FA2H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP286 grouped by FA2H-low versus FA2H-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FA2H→partner) and Y-score (partner→FA2H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP286 →	+0.096	+6.225	<.001	<.001	3	2
UCEC	HMGN2P26 →	+0.108	+2.814	.001	.001	3	2
KIRP	RN7SL553P →	+0.160	+6.528	<.001	.001	3	2
UCEC	TRBV7-9 →	+0.686	+2.593	.008	.006	3	1
UCEC	TMEM150B →	+0.546	+2.425	.003	.002	3	1
UCEC	CCDC43 →	+0.440	+2.447	.009	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 704 associations by consensus.

RN7SKP286 by FA2H expression — SKCM

Explore this box plot interactively →