FA2H

Across TCGA pan-cancer cohorts, FA2H RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FA2H’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FA2H RNA is repressed in tumor relative to normal tissue. In most cancer types FA2H is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LUAD are the cancer types where FA2H tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FA2H RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.303	<.001	11	view →
THCA	All	IV	−1.597	<.001	11	view →
LUAD	Male	II,III,IV	+2.528	<.001	9	view →
UCEC	All	All	+1.472	<.001	6	view →
BRCA	All	III,IV	+0.968	.006	6	view →
CHOL	Female	All	+4.399	<.001	5	view →
KICH	Female	II,III,IV	+2.099	<.001	4	view →
KIRP	Male	All	−1.078	.001	4	view →
STAD	Male	All	+1.323	.021	2	view →
PRAD	All	All	+0.561	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FA2H–KIRC

Open the KIRC breakdown →