FA2H

Across TCGA pan-cancer cohorts, FA2H RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated FA2H data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FA2H RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FA2H expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

LUAD, HNSC, and BLCA are the cancer types where FA2H RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.577	0.738	<.001	99	view →
HNSC	OS	Median	IV	0.431	0.297	.004	68	view →
BLCA	OS	Median	All	0.791	0.649	.002	42	view →
MESO	DFS	Median	II,III,IV	0.285	0.462	.002	41	view →
SCLC	OS	Median	All	0.774	0.516	.006	37	view →
KIRP	DFS	Median	IV	0.036	0.526	.002	36	view →
ESCA	OS	Median	All	0.577	1.000	.005	30	view →
KIRC	OS	Median	All	0.846	0.900	.008	21	view →
LIHC	OS	Quartile	All	0.661	0.842	.006	18	view →
PRAD	DFS	Median	All	0.940	0.830	<.001	18	view →
THCA	DFS	Median	II,III,IV	0.259	0.886	.005	15	view →
PAAD	OS	Quartile	All	0.359	0.649	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

FA2H–LUAD (DFS)

Open the LUAD breakdown →