FA2H

Across TCGA cell cohorts, FA2H mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FA2H-associated genes across cancer lineages are TTLL8, ECE2, and ELOA3DP. Each is linked with FA2H in more than 1 cancer types. Because this analysis shows association rather than direction, both FA2H-to-partner and partner-to-FA2H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTLL8 grouped by FA2H-low versus FA2H-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FA2H→partner) and Y-score (partner→FA2H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTLL8 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ECE2 →	+0.295	+4.376	<.001	<.001	3	1
LARGE_INTESTINE	ELOA3DP →	+0.036	+3.688	<.001	.002	3	1
LARGE_INTESTINE	H4C13 →	+0.324	+3.592	.001	.006	3	1
LUNG_SCLC	KRTAP9-4 →	+0.020	+4.643	<.001	.004	3	1
LUNG_SCLC	OR6J1 →	+0.025	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TTLL8 by FA2H expression — LARGE_INTESTINE

Explore this box plot interactively →