F9

Across TCGA patient cohorts, F9 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible F9-associated genes across cancer lineages are FoxM1, p27_pT198, and PCNA. Each is linked with F9 in more than 2 cancer types. Because this analysis shows association rather than direction, both F9-to-partner and partner-to-F9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by F9-low versus F9-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F9→partner) and Y-score (partner→F9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FoxM1 →	+0.323	+2.840	.006	.033	3	3
LUSC	p27_pT198 →	+0.196	+2.816	.016	.036	3	2
UCEC	PCNA →	+0.239	+2.137	.001	.001	3	2
UCEC	Cyclin-B1 →	+0.724	+2.137	<.001	.001	3	2
UCEC	eIF4E →	+0.155	+3.335	.031	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.144	-2.000	.012	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

FoxM1 by F9 expression — LUAD

Explore this box plot interactively →