F13B

Across TCGA patient cohorts, F13B mutation is significantly associated with the RNA expression of many other genes, with 4,810 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible F13B-associated genes across cancer lineages are METTL22, H2BC17, and PGK1. Each is linked with F13B in more than 3 cancer types. Because this analysis shows association rather than direction, both F13B-to-partner and partner-to-F13B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, METTL22 grouped by F13B-low versus F13B-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F13B→partner) and Y-score (partner→F13B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	METTL22 →	+0.285	+2.271	.004	.001	3	4
UCEC	H2BC17 →	+0.634	+1.917	<.001	<.001	3	3
UCEC	PGK1 →	+0.548	+1.688	.003	.001	3	3
UCEC	PSMD7 →	+0.405	+1.688	.001	.001	3	3
UCEC	AAGAB →	+0.393	+1.528	<.001	.002	3	3
SKCM	KRR1 →	+0.451	+1.587	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,810 associations by consensus.

METTL22 by F13B expression — LUSC

Explore this box plot interactively →